What We Do and Why It Matters
The Mellone Lab studies how genetic information is accurately passed from one cell generation to the next. Our work focuses on centromeres, essential chromosome regions that direct the precise distribution of chromosomes to daughter cells during division. Using the fruit fly Drosophila melanogaster as our model system, we investigate how centromeres are built, maintained, and evolve. Taking advantage of the powerful genetic tools available in flies, we study how DNA sequences and proteins work together to create functional centromeres. By tackling fundamental biological questions in genome biology, our work indirectly paves the way for advancements in genome editing, cancer biology, genome stability, and informs future biotechnology applications.
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The image at the top of the page shows synchronously dividing early Drosophila embryo stained for tubulin (red) and DNA (green). Image by Dr. Leah Rosin