Please contact Barbara.Mellone [at] uconn.edu for pdfs of any of these publications
Articles
Chabot B.J., Sun R.*, Amjad A.*, Hoyt S.J.*, Ouyang L., Courret C., Leo L., Larracuente A.M., Core L.J., O’Neill R.J., Mellone B.G. Transcription of a centromere-enriched retroelement and local retention of its RNA are significant features of the CENP-A chromatin landscape. Genome Biol 25, 295 (2024). Link doi.org/10.1186/s13059-024-03433-1
*equal contributors
Courret C, Hemmer L, Wei X, Patel PD, Chabot BJ, Fida NJ, Geng X, Chang C-H, Mellone BG, Larracuente A.M. Turnover of retroelements and satellite DNA drives centromere reorganization over short evolutionary timescales in Drosophila. PLOS Bio (2024). Link doi.org/10.1371/journal.pbio.3002911
Patchigolla VSP. and Mellone BG. Enrichment of non-B-form DNA at D. melanogaster centromeres. Genome Biology and Evolution, Volume 14, Issue 5, (2022), evac054. Link
Antel M, Masoud M, Raj R, Pan Z, Mellone BG, Inaba M. Interchromosomal interaction of homologous Stat92E alleles regulates transcriptional switch during stem-cell differentiation. Nature Comm. (2022) 13: 3981. Link
Palladino J, Chavan A, Sposato A, Mason TD, and Mellone BG. Targeted de novo centromere formation in Drosophila reveals plasticity and maintenance potential of CENP-A chromatin. Dev Cell (2020) Feb 10;52(3):379-394.e7. Link
-Issue Cover
-Highlighted in: De Novo Centromere Formation: One’s Company, Two’s a Crowd. Dev Cell, Feb 10;52(3):257-258. Link
-Media: UConn Today
Chang, C-H*, Chavan, A*, Palladino, J*, Wei, X, Martins, NMC, Santinello, B, Chen, C-C, Erceg, J, Beliveau, BJ, Wu, C-T, Larracuente, AM#, Mellone, BG#. Islands of retroelements are major components of Drosophila centromeres. PLoS Biology. (2019) May 14. Link
-* equal contributors
-# corresponding authors
- Media coverage
- Recommended by Faculty of 1000 Link
Rosin, L, and Mellone BG. Co-evolving CENP-A and CAL1 domains mediate centromeric CENP-A deposition across Drosophila species. Dev Cell. (2016) Apr 18; 37(2):136-147. Link
-Highlighted in: Centromeres of a different CAL-iber. Dev Cell. 2016 Apr 18; 37(2):105-106. Link
-Recommended by Faculty of 1000 Link
Chen, C-C, Bowers, S, Lipinski, Z, Trusiak, S, Palladino, J, Bettini, E, Rosin, L, Przewloka, M, Glover, D, O’Neill, R, Mellone, BG. Establishment of centromeric chromatin by the CENP-A assembly factor CAL1 requires FACT-mediated transcription. Dev Cell. (2015) Jul 6;34(1):73-84. Link
Chen, C-C*, Dechassa, ML*, Bettini, E, Belisario, C, Ledoux, M, Heun, P, Luger, K, Mellone, BG. CAL1 is the Drosophila CENP-A assembly factor. J Cell Biol. (2014) Feb 3; 204(3):313-29. Link
-Highlighted in: CAL1 builds centromeres on the fly. J Cell Biol. 2014 Feb 3; 204:282. Link
-Recommended by Faculty of 1000 Link
-*equal contributors
Ross, BD, Rosin, L, Thomae AW, Hiatt, MA, Vermaak, D, de la Cruz AF, Imhof A, Mellone, BG, Malik, HS. Stepwise evolution of essential centromere function in a Drosophila neogene. Science, (2013) Vol. 340 no. 6137 pp. 1211-1214. Link
Chen C.C, Greene E, Bowers SR, Mellone BG. A Role for the CAL1-Partner Modulo in Centromere Integrity and Accurate Chromosome Segregation in Drosophila. PLoS ONE (2012) 7(9): e45094. doi:10.1371/journal.pone.0045094
Bateman,JR, Larschan, E, D’Souza, R, Marshall,LS, Dempsey, KE, Johnson, JE, Mellone, BG. and Kuroda, MI. Genome-Wide Screen Identifies Genes That Affect Somatic Homolog Pairing in Drosophila. G3: Genes, Genomes, Genetics (2012). doi: 10.1534/g3.112.002840
Phansalkar R, Lapierre P, and Mellone BG. Evolutionary insights into the role of the essential centromere protein CAL1 in Drosophila. Chromosome Res (2012), DOI: 10.1007/s10577-012-9299-7
Kuratnik A, Senapati VE, Verma R, Mellone BG, Vella AT, Giardina C. 2012. Acute sensitization of colon cancer cells to inflammatory cytokines by prophase arrest. Biochem Pharmacol. 2012 Jan 25.
Mellone BG#, Grive KJ, Shteyn V, Bowers SR, Oderberg I, Karpen GH#. Assembly of Drosophila Centromeric Chromatin Proteins during Mitosis. PLoS Genet (2011) 7(5): e1002068. doi:10.1371/journal.pgen.1002068 Link
-Issue cover
-#corresponding author
Williamson A*, Wickliffe KE*, Mellone BG, Song L, Karpen GH, Rape M. Identification of a physiological E2 module for the human anaphase-promoting complex. Proc Natl Acad Sci U S A. (2009).
Erhardt S*, Mellone BG*, Betts CM*, Karpen GH, Straight AF. Identification of novel regulators of centromeric chromatin by genome-wide RNAi screening. J Cell Biol. (2008) Dec 1;183(5):805-18. Link
-* equal contributors
Castillo AG*, Mellone BG*, Partridge JF, Richardson W, Hamilton GL, Allshire RC, Pidoux AL. Plasticity of Fission Yeast CENP-A Chromatin Driven by Relative Levels of Histone H3 and H4. PLoS Genet. (2007) Jul 27;3(7):e121. Link
-* equal contributors
Zhang W, Mellone BG, Karpen GH. A specialized nucleosome has a ‘point’ to make. (Preview). Cell. (2007) Jun 15;129(6):1047-9.
Mellone B, Erhardt S, Karpen GH. The ABCs of centromeres. Nature Cell Biology. (2006) May;8(5):427-9. (News & Views).
Pidoux A, Mellone B, Allshire R.C. Analysis of chromatin in Fission Yeast. Methods. (2004) Jul;33(3):252-9.
Mellone BG, Ball L, Suka N, Grunstein MR, Partridge JF, Allshire RC. Centromere function in fission yeast is governed by the amino terminus of histone H3. Current Biology (2003), Oct 14; 13(20): 1748-1757. Link
Mellone BG and Allshire RC. Stretching it: Putting the CEN(P-A) in centromere. Current Opinion in Genetics and Development. (2003) Vol 13 No 2 April (Review). Link
Kniola B, O'Toole E, McIntosh JR, Mellone B, Allshire R, Mengarelli S, Hultenby K, Ekwall K. The domain structure of centromeres in conserved from fission yeast to humans. Molecular Biology of the Cell. (2001) Sept 1; 12 (9).
*equal contributors
Courret C, Hemmer L, Wei X, Patel PD, Chabot BJ, Fida NJ, Geng X, Chang C-H, Mellone BG, Larracuente A.M. Turnover of retroelements and satellite DNA drives centromere reorganization over short evolutionary timescales in Drosophila. PLOS Bio (2024). Link doi.org/10.1371/journal.pbio.3002911
Patchigolla VSP. and Mellone BG. Enrichment of non-B-form DNA at D. melanogaster centromeres. Genome Biology and Evolution, Volume 14, Issue 5, (2022), evac054. Link
Antel M, Masoud M, Raj R, Pan Z, Mellone BG, Inaba M. Interchromosomal interaction of homologous Stat92E alleles regulates transcriptional switch during stem-cell differentiation. Nature Comm. (2022) 13: 3981. Link
Palladino J, Chavan A, Sposato A, Mason TD, and Mellone BG. Targeted de novo centromere formation in Drosophila reveals plasticity and maintenance potential of CENP-A chromatin. Dev Cell (2020) Feb 10;52(3):379-394.e7. Link
-Issue Cover
-Highlighted in: De Novo Centromere Formation: One’s Company, Two’s a Crowd. Dev Cell, Feb 10;52(3):257-258. Link
-Media: UConn Today
Chang, C-H*, Chavan, A*, Palladino, J*, Wei, X, Martins, NMC, Santinello, B, Chen, C-C, Erceg, J, Beliveau, BJ, Wu, C-T, Larracuente, AM#, Mellone, BG#. Islands of retroelements are major components of Drosophila centromeres. PLoS Biology. (2019) May 14. Link
-* equal contributors
-# corresponding authors
- Media coverage
- Recommended by Faculty of 1000 Link
Rosin, L, and Mellone BG. Co-evolving CENP-A and CAL1 domains mediate centromeric CENP-A deposition across Drosophila species. Dev Cell. (2016) Apr 18; 37(2):136-147. Link
-Highlighted in: Centromeres of a different CAL-iber. Dev Cell. 2016 Apr 18; 37(2):105-106. Link
-Recommended by Faculty of 1000 Link
Chen, C-C, Bowers, S, Lipinski, Z, Trusiak, S, Palladino, J, Bettini, E, Rosin, L, Przewloka, M, Glover, D, O’Neill, R, Mellone, BG. Establishment of centromeric chromatin by the CENP-A assembly factor CAL1 requires FACT-mediated transcription. Dev Cell. (2015) Jul 6;34(1):73-84. Link
Chen, C-C*, Dechassa, ML*, Bettini, E, Belisario, C, Ledoux, M, Heun, P, Luger, K, Mellone, BG. CAL1 is the Drosophila CENP-A assembly factor. J Cell Biol. (2014) Feb 3; 204(3):313-29. Link
-Highlighted in: CAL1 builds centromeres on the fly. J Cell Biol. 2014 Feb 3; 204:282. Link
-Recommended by Faculty of 1000 Link
-*equal contributors
Ross, BD, Rosin, L, Thomae AW, Hiatt, MA, Vermaak, D, de la Cruz AF, Imhof A, Mellone, BG, Malik, HS. Stepwise evolution of essential centromere function in a Drosophila neogene. Science, (2013) Vol. 340 no. 6137 pp. 1211-1214. Link
Chen C.C, Greene E, Bowers SR, Mellone BG. A Role for the CAL1-Partner Modulo in Centromere Integrity and Accurate Chromosome Segregation in Drosophila. PLoS ONE (2012) 7(9): e45094. doi:10.1371/journal.pone.0045094
Bateman,JR, Larschan, E, D’Souza, R, Marshall,LS, Dempsey, KE, Johnson, JE, Mellone, BG. and Kuroda, MI. Genome-Wide Screen Identifies Genes That Affect Somatic Homolog Pairing in Drosophila. G3: Genes, Genomes, Genetics (2012). doi: 10.1534/g3.112.002840
Phansalkar R, Lapierre P, and Mellone BG. Evolutionary insights into the role of the essential centromere protein CAL1 in Drosophila. Chromosome Res (2012), DOI: 10.1007/s10577-012-9299-7
Kuratnik A, Senapati VE, Verma R, Mellone BG, Vella AT, Giardina C. 2012. Acute sensitization of colon cancer cells to inflammatory cytokines by prophase arrest. Biochem Pharmacol. 2012 Jan 25.
Mellone BG#, Grive KJ, Shteyn V, Bowers SR, Oderberg I, Karpen GH#. Assembly of Drosophila Centromeric Chromatin Proteins during Mitosis. PLoS Genet (2011) 7(5): e1002068. doi:10.1371/journal.pgen.1002068 Link
-Issue cover
-#corresponding author
Williamson A*, Wickliffe KE*, Mellone BG, Song L, Karpen GH, Rape M. Identification of a physiological E2 module for the human anaphase-promoting complex. Proc Natl Acad Sci U S A. (2009).
Erhardt S*, Mellone BG*, Betts CM*, Karpen GH, Straight AF. Identification of novel regulators of centromeric chromatin by genome-wide RNAi screening. J Cell Biol. (2008) Dec 1;183(5):805-18. Link
-* equal contributors
Castillo AG*, Mellone BG*, Partridge JF, Richardson W, Hamilton GL, Allshire RC, Pidoux AL. Plasticity of Fission Yeast CENP-A Chromatin Driven by Relative Levels of Histone H3 and H4. PLoS Genet. (2007) Jul 27;3(7):e121. Link
-* equal contributors
Zhang W, Mellone BG, Karpen GH. A specialized nucleosome has a ‘point’ to make. (Preview). Cell. (2007) Jun 15;129(6):1047-9.
Mellone B, Erhardt S, Karpen GH. The ABCs of centromeres. Nature Cell Biology. (2006) May;8(5):427-9. (News & Views).
Pidoux A, Mellone B, Allshire R.C. Analysis of chromatin in Fission Yeast. Methods. (2004) Jul;33(3):252-9.
Mellone BG, Ball L, Suka N, Grunstein MR, Partridge JF, Allshire RC. Centromere function in fission yeast is governed by the amino terminus of histone H3. Current Biology (2003), Oct 14; 13(20): 1748-1757. Link
Mellone BG and Allshire RC. Stretching it: Putting the CEN(P-A) in centromere. Current Opinion in Genetics and Development. (2003) Vol 13 No 2 April (Review). Link
Kniola B, O'Toole E, McIntosh JR, Mellone B, Allshire R, Mengarelli S, Hultenby K, Ekwall K. The domain structure of centromeres in conserved from fission yeast to humans. Molecular Biology of the Cell. (2001) Sept 1; 12 (9).
Reviews & Commentaries
Santinello B and Mellone B.G. Cell biology: Centromere instability and replication stress underlie Xenopus hybrid incompatibility. Current Biology, Volume 32, Issue 18, PR947-R949, September 26, 2022. (Dispatch) Link
Mellone, BG, Fachinetti, D. Diverse mechanisms of centromere specification. Current Biol. 2021 Nov 31, 1491-1504. (Review) Link
Rosin, L and Mellone, BG. Centromeres drive a hard bargain. Trends in Genetics. 2017 Feb 33; 2; 101-117. (Review) Link
-Selected as Free Featured Article
Chen, CC and Mellone, BG. Chromatin assembly: Journey to the CENter of the chromosome. J Cell Biol. 2016 Jul 4;214(1):13-24 (Review). Link
Palladino, J and Mellone, BG. The Kat’s out of the bag: histone acetylation promotes centromere assembly. Dev Cell. 2016 Jun 6;37(5):389-90 (Preview).
Earnshaw, WC, [...], Mellone BG, et al. Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant. Chromosome Res. 2013 Apr;21(2):101-6.
Bowers SR and Mellone BG. Starting from scratch: de novo kinetochore assembly in vertebrates. EMBO J. 2011 Sep 6;30(19):3882-4.
Mellone BG, Zhang W, Karpen GH. Frodos found: Behold the CENP-A “Ring” bearers. (Preview). Cell. 173. 2009.
Mellone BG. Spatial and temporal regulation of centromeric chromatin. Biochemistry and Cell Biology. 2009 Feb;87(1):255-64.
Mellone, BG, Fachinetti, D. Diverse mechanisms of centromere specification. Current Biol. 2021 Nov 31, 1491-1504. (Review) Link
Rosin, L and Mellone, BG. Centromeres drive a hard bargain. Trends in Genetics. 2017 Feb 33; 2; 101-117. (Review) Link
-Selected as Free Featured Article
Chen, CC and Mellone, BG. Chromatin assembly: Journey to the CENter of the chromosome. J Cell Biol. 2016 Jul 4;214(1):13-24 (Review). Link
Palladino, J and Mellone, BG. The Kat’s out of the bag: histone acetylation promotes centromere assembly. Dev Cell. 2016 Jun 6;37(5):389-90 (Preview).
Earnshaw, WC, [...], Mellone BG, et al. Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant. Chromosome Res. 2013 Apr;21(2):101-6.
Bowers SR and Mellone BG. Starting from scratch: de novo kinetochore assembly in vertebrates. EMBO J. 2011 Sep 6;30(19):3882-4.
Mellone BG, Zhang W, Karpen GH. Frodos found: Behold the CENP-A “Ring” bearers. (Preview). Cell. 173. 2009.
Mellone BG. Spatial and temporal regulation of centromeric chromatin. Biochemistry and Cell Biology. 2009 Feb;87(1):255-64.
Preprints
Santinello B, Sun R, Amjad A, Hoyt SJ, Ouyang L, Courret C, Drennan R, Leo L, Larracuente AM2, Core, LM, O’Neill RJ, Mellone BG*. A centromere-derived retroelement RNA localizes in cis and is a core element of the transcriptional landscape of Drosophila centromeres. BioRxiv 574223 [Preprint]. 2024 Jan14. Doi: https://doi.org/10.1101/2024.01.14.574223 Link
Courret C, Hemmer L, Wei X, Patel PD, Santinello B, Geng X, Chang C-H, Mellone B, Larracuente AM.
Rapid turnover of centromeric DNA reveals signatures of genetic conflict in Drosophila. BioRXiv 2023 https://doi.org/10.1101/2023.08.22.554357. Link
Patchigolla V.S.P. and Mellone B. G. Enrichment of non-B-form DNA at D. melanogaster centromeres. BioRxiv 2021.12.20.473213. doi: https://doi.org/10.1101/2021.12.20.473213. Link
Antel M, Masoud M, Raj R, Pan Z, Li S, Mellone BG, Inaba M. Interchromosomal interaction of homologous Stat92E alleles regulates transcriptional switch during stem-cell differentiation. BioRXiv 2021.11.08.467622. doi: https://doi.org/10.1101/2021.11.08.467622. Link
Courret C, Hemmer L, Wei X, Patel PD, Santinello B, Geng X, Chang C-H, Mellone B, Larracuente AM.
Rapid turnover of centromeric DNA reveals signatures of genetic conflict in Drosophila. BioRXiv 2023 https://doi.org/10.1101/2023.08.22.554357. Link
Patchigolla V.S.P. and Mellone B. G. Enrichment of non-B-form DNA at D. melanogaster centromeres. BioRxiv 2021.12.20.473213. doi: https://doi.org/10.1101/2021.12.20.473213. Link
Antel M, Masoud M, Raj R, Pan Z, Li S, Mellone BG, Inaba M. Interchromosomal interaction of homologous Stat92E alleles regulates transcriptional switch during stem-cell differentiation. BioRXiv 2021.11.08.467622. doi: https://doi.org/10.1101/2021.11.08.467622. Link